A novel synthesis of the oxazolidinone antithrombotic agent rivaroxaban.
نویسندگان
چکیده
A facile synthetic route of rivaroxaban has been developed. Using commercially available (R)-epichlorohydrin and bromobenzene as the starting materials, rivaroxaban was obtained in 39% overall yield using a Goldberg coupling as the key step. The synthetic route represents a convenient procedure for the production of rivaroxaban.
منابع مشابه
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ورودعنوان ژورنال:
- Molecules
دوره 19 9 شماره
صفحات -
تاریخ انتشار 2014